WHAT IS IT?: This agent based model examines differences in innate immune mechanisms between bats and humans. This model is largely focused on differences in inflammatory response in bats versus humans. Simulation experiments demonstrate the efficacy of bat-related features in conferring viral tolerance and also suggest a crucial role for endothelial inflammasome activity as a possible explanation of the diffidence in viral tolerance between bats and humans.
Bat - Human Comparative Model in NetLogo.
Model Location: This model can be run online at NetLogo using https://netlogoweb.org/web?https://raw.githubusercontent.com/An-Cockrell/Comparative-Biology-Immune-ABM/main/CBIABM3.0%20V2.0v5_PublishedV2.
To Run: Click the buttons in the upper left "Setup", "Infect" then "Go". Scroll down and click the "Model Info" tab to get a brief description of the model or visit the reference link below.
How it was built: This model is implemented in NetLogo (https://ccl.northwestern.edu/netlogo/). For help on using this model in NetLogo model see https://www.mdpi.com/article/10.3390/v13081620/s1. In addition, the entire project can be obtained from the GitHub repository at https://github.com/An-Cockrell/Comparative-Biology-Immune-ABM.
Reference: Cockrell C, An G. Comparative Computational Modeling of the Bat and Human Immune Response to Viral Infection with the Comparative Biology Immune Agent Based Model. Viruses. 2021 Aug 16;13(8):1620. doi: 10.3390/v13081620. PMID: 34452484; PMCID: PMC8402910.